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Eva edelman, eva edelman contact, healing bipolar book, natural healing for bipolar, questions for edelman, talk to eva edelman wednesday, march 28, 2012 histadelia and methylation. Part v-a: transsulfuration pathway homocysteine despite the notorious dangers of excess homocysteine,* normal levels are necessary to body chemistry, particularly the methylation cycle and the transsulfuration pathway. Homocysteine lies at the intersection of the two, serving as a precursor to methionine (which forms sam), and also as the antecedent to cysteine, taurine, glutathione and sulfate. * chronically elevated homocysteine is infamous for its association with heart disease and may also play a role in memory impairment. It degrades collagen and elastin and damages the lining of blood and lymphatic vessels, via oxidative stress, inflammation, fibrin deposits, etc.   similarly, it compromises the blood brain barrier. cheap generic viagra buy cheap viagra viagra online viagra without a doctor prescription viagra for sale cheap generic viagra cheap viagra online canadian pharmacy cheap viagra generic viagra online viagra without a doctor prescription The transsulfuration pathway ( under the methionine cycle (4) on the bottom right of this diagram ) during the methylation cycle, insufficient glutathione at the homocysteine-to-methionine step prevents methyl from linking to b12, and thereby impedes methionine formation. Homocysteine  is instead diverted down the transsulfuration pathway to form glutathione. This pathway transforms homocysteine into sulfur antioxidants and detox agents. And typically removes half the homocysteine from the methylation cycle.   but when it goes wrong, it produces toxic sulfur compounds.   here is an introduction to the chemistry: essentially:  homocysteine with the help of:          vitamin b6 (as p5p), vitamin b3 (as nad),          magnesium, serine, selenium, molybdenum and oxygen                        produces cysteine, glutathione, taurine and sulfate.   or, lacking required nutrients or energy, or with sulfur accumulation or dietary sulfur overload:       homocysteine forms cystine (instead of cysteine), excessive ammonia,  hydrogen sulfide and other toxic sulfur compounds. Specifically (enzymes are in parenthesis): 1 homocysteine  + b6  (as p5p*) + mg   (via cbs)  yields cysteine (+ akg** + ammonia). 2 cysteine + serine + selenium + glutamate   yields  glutathione. 3 cysteine   + vitamin b3   (as nad)   yields  taurine. 4a s ulfite (from cyst.
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